Mayor of London Boris Johnson has officially opened the News Building at London Bridge.
The ceremony on Tuesday marked the completion of the move by News UK titles The Times, The Sunday Times and The Sun from downstream Wapping across the river.
Last weekend saw the arrival of The Times Literary Supplement.
Around 2,400 employees now occupy the building in London Bridge Street and a further 1,000 from Dow Jones and HarperCollins will be arriving over coming months.
The Mayor, who described the building as "nestled next to the giant cosmic spear that is The Shard", was welcomed by executive chairman Rupert Murdoch, CEO Robert Thomson and News UK CEO Mike Darcey.
"Today marks a critical milestone for our world class journalism – the inimitable headlines, game-changing polls, first class commentary and courageous investigations," said Mike Darcey.
"Our journalism sets the agenda and sets the standards and in this home I am confident we will secure its future for generations."
Earlier, as part of its commitment to be a good neighbour in the community, News UK donated 88 Nexus and iPad tablets to Southwark's public libraries.
Speaking to London SE1 website after the presentation, Mike Darcey said that the move had been "an incredible experience".
"The whole building feels energised. People are delighted with the space they have got in the building. They are delighted with the transport links."
He added: "It does slightly feel like a new beginning."
Community guests at the News Building opening included Mayor of Southwark Sunil Chopra, Southwark Council leader Peter John, Dean of Southwark the Very Revd Andrew Nunn, Southwark & Lambeth London Assembly member Val Shawcross and Bermondsey & Old Southwark MP Simon Hughes.