The Presiding Bishop and Primate of the Episcopal Church in the United States of America, the Most Revd Katharine Jefferts Schori, will preach and preside at the Choral Eucharist.
This is believed to be the first time that she has both preached and presided at an English Cathedral.
During her visit to Southwark she will have the opportunity to meet and talk to members of the staff and congregation.
"I am really pleased that Dr Jefferts Schori has agreed to preach and preside at Southwark Cathedral," says the dean, Very Revd Colin Slee.
"We have had a number of Primates come to visit us in this way and it is always a great blessing to hear from and learn about other parts of the Anglican Communion."