The Queen stopped off at St Saviour's and St Olave's School to join in the centenary celebrations.
The school, alongside the Bricklayers Arms flyover, opened on the Old Kent Road site a century ago. The opening ceremony in 1903 was performed by the future George V, Elizabeth II's grandfather.
The Queen saw students at work on design and technology projects and sat on the platform during an assembly. The same stage was last in the news when the Prime Minister launched his General Election campaign at the school.
Afterwards the Queen travelled to Greenwich where she was joined by Prince Philip at the Queen Elizabeth I Exhibition at the National Maritime Museum.