Dan Abramson has been appointed as the first head of the new King's College London Mathematics School which is due to open in Waterloo next autumn.
Mr Abramson has been head of mathematics at Highgate School in North London since 2007.
King's announced its plans to open a sixth form free school specialising in mathematics last December and the college is continuing to examine potential sites for the school in and around Waterloo.
"I am delighted to take up such an instrumental role in this game-changing school," said Dan Abramson.
"King's College London Mathematics School will change the educational landscape as we know it, by bringing high quality mathematics teaching to those for whom such experiences have not easily been available.
"For those pupils who have a particular aptitude and enthusiasm for mathematics, it will provide the opportunity to move on to degrees in mathematics and other STEM subjects at the best universities in the country.
"I'm also excited about developing the partnership between school and university, since it provides such a rich opportunity to strengthen the links between secondary and tertiary education."
He added: "I want King's College London Mathematics School to become the top provider of mathematicians, physicists, engineers, statisticians and computer scientists in the country."