Dr Irene Bishop, headteacher of St Saviour's & St Olave's Girls' School at Bricklayers Arms, has been awarded the CBE in the Queen's birthday honours list.
Dr Bishop is also currently serving as executive headteacher of St Michael and All Angels Academy in Camberwell and is co-director of the Southwark Schools' Learning Partnership.
In the Queen's birthday honours list, published on Saturday, Professor Robert Lechler, executive director of King's Health Partners and a former deputy chair of Guy's & St Thomas' NHS Foundation Trust, is knighted for services to academic medicine.
The same award is bestowed on Professor Andy Adam, professor of interventional radiology at St Thomas' Hospital.
Local resident Prem Goyal receives an OBE for services to to economy and promoting charitable giving. Causes supported by Mr Goyal include the Tayo Situ Foundation which was established in memory of the late Mayor of Southwark. He is also a trustee of Rotherhithe-based Time and Talents and a leading supporter of the local Labour Party.
Last month Mr Goyal met the Queen during her visit to South London when he represented Southwark at a Diamond Jubilee lunch in Merton.
Professor Mary Lovegrove, who retired last year as head of the allied healthcare sciences department at London South Bank University, receives the OBE.
The same honour is awarded to Professor Jeffrey Weeks, research professor of sociology at LSBU and a leading authority on sexuality and gender. The university's Weeks Centre for Social and Policy Research is named after him.
Melinda Edwards, consultant clinical psychologist at the Evelina Children's Hospital, is awarded the MBE for services to children with chronic and life-threatening medical conditions.