Sainsbury's has applied to Southwark Council for planning permission to turn the ground floor of a hotel into a convenience food store.
Last year Southwark councillors granted retrospective consent for the 52-bedroom hotel known as Accommodation London Bridge which had opened without permission in a former office building.
Now the hotel's owners Europa Gold have submitted a joint planning application with Sainsbury's Supermarkets to turn most of the building's ground floor into a convenience food store.
Sainsbury's says that the proposed store will be open daily 7am-11pm. A new shopfront would be created on Great Dover Street including a cash machine.