David Lan is to step down after 17 years as artistic director of the Young Vic theatre in Waterloo.
In a statement, the theatre's board said: "Over the 17 years of his tenure, the Young Vic's reputation has grown to become one of the most admired theatres in the world."
He oversaw the award-winning project to rebuild the theatre on The Cut.
David Lan said: "There is never an easy time to slip away but I wanted to leave at a time of our greatest strength and success. The Young Vic is now admired and emulated internationally as well as loved by our audience in Waterloo, in London and across the UK. It's the right moment for it to set off on a new journey and a new adventure."
David Lan will continue as artistic director and CEO until a new artistic director is appointed towards the end of this year and will continue to take responsibility for the 2017/18 season, his last at the Young Vic, which will be announced in mid July.
Lucy Woollatt will continue to lead the company as executive director.