Hercules Road was closed to traffic on Friday lunchtime as firefighters tackled a fire in a house near the junction with Virgil Street.
The London Fire Brigade was called to the scene at 1.28pm to reports of smoke coming from the three-storey house.
Fire engines from Lambeth and Old Kent Road fire stations were dispatched and the blaze was under control within 20 minutes.
A brigade spokeswoman told the London SE1 website that the cause of the fire is under investigation.
For the latest local news and events direct to your inbox every Monday, you need our weekly email newsletter SE1 Direct.
7,000+ locals read it every week. Can you afford to miss out?
Read the latest issue before signing up