A new Sainsbury's Local convenience store has opened at Friars House in Blackfriars Road.
The new shop has chosen the Muscular Dystrophy Campaign, based in Great Suffolk Street, as its charity partner.
Sainsbury's has installed a cash machine which is the only ATM on the southern half of Blackfriars Road.
The Practical Law Company will soon move into the offices above the supermarket.
A Pret a Manger sandwich shop will open next to Sainsbury's in the coming days.
The new store is situated just 250 metres from the Sainsbury's Local branch which opened last year in The Cut.