Marks & Spencer's long-awaited Simply Food store on Southwark Street opens on Wednesday 4 June.
The 7,700 sq ft store will stock more than 2,800 products including ready meals, fresh produce, sandwiches, salads and snacks. The branch features a coffee and hot food counter.
The store, which opens for the first time at 10am on Wednesday 4 June, will employ 75 people.
Opening hours will be 7am-10pm on weekdays, 8am-8pm on Saturdays and 11am-5pm on Sundays.
The M&S store is at the base of the office building known as Bankside 3 which – along with Bankside 2 – is to be occupied by the Royal Bank of Scotland.
RBS wants to treat the two buildings as a single unit and proposes to build a bridge link between the two blocks at levels 2 to 8.