Thames Water has announced plans to close Stamford Street to eastbound traffic from early October until early April 2011.
The work is part of Thames Water's programme to replace Victorian cast iron pipes with plastic ones.
There will be weekend closures to westbound traffic on 21 & 22 August, 28-30 August and 25 & 26 September.
Two-way traffic is due to be reinstated in early April 2011.
Householders and businesses will receive individual notification of temporary interruptions to water supply during the works.