Stamford Street is closed to eastbound traffic for six months whilst Thames Water carry out works to replace Victorian water mains.
In August we revealed Thames Water's plans for a six-month partial closure of the street.
The eastbound road closure starts at 8pm on Sunday 17 October and is expected to be lifted on Friday 8 April 2011
Transport for London is warning of "severe delays" to buses on routes RV1 and 381 which will both be subject to lengthy eastbound diversions.
The diversion means that passengers on the RV1 travelling between Covent Garden and London Bridge will travel twice around the Waterloo roundabout by the BFI IMAX.
TfL says that bus drivers have been instructed to serve bus stops on the diversion routes on request.