Pedestrians will be unable to cross the Millennium Bridge between 9.30am and 4.30pm from Monday to Thursday this week.
Contractors working for the City of London Corporation will be carrying out their regular structural inspection of the 10-year-old bridge which links the City of London with Bankside.
These temporary off-peak closures have been a regular occurrence since 2005.
Some parts of the inspection will involve contractors checking the structure using roped access.
A safety boat will be on standby whilst the inspection takes place.
It is a decade since work was carried out to cure the river crossing of the problems that earnt it the 'wobbly bridge' nickname.
The bridge opened to the public for just three days in June 2000 before it was sealed off for work to correct the violent swaying motion that pedestrians experienced.
The bridge did not reopen until February 2002.