TfL has launched a two-week public consultation on their plans for the section of the road between Bricklayers Arms and Grange Walk.
The pavements on Tower Bridge Road will be revpaved with york stone and the public space will be decluttered.
A new diagonal pedestrian crossing from Trocette Mansions to the Ruby Nails salon is also proposed.
Loading bays will be reorganised and new cycle parking will be installed.
Changes to the junction with Rothsay Street and Webb Street will be announced as part of a separate project to design the Quietway cycle route between Greenwich and Waterloo.
Full details are available on the TfL consultation website; the closing date for responses is Tuesday 15 April.
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