The Blue Fin Building on Southwark Street has been put up for sale by its American owners Time Inc.
Magazine publisher IPC Media moved to the newly built Blue Fin Building in 2007.
Last year the company adopted the name of its American parent company Time Inc.
"Today, we are announcing that we have listed for sale the Blue Fin Building, our principal executive offices in the UK," said Time Inc in its quarterly results announcement.
"This approximately 500,000 square foot property is a marquee building in central London.
"We expect that Time Inc UK, which currently occupies approximately 228,000 square feet in the building, will remain a tenant following any sale."
The Blue Fin Building was built as part of Land Securities's Bankside 123 development and was originally known as Bankside 1.