Carly Moran of St Saviour's and St Olave's School and Victoria Panayi of Notre Dame Girls' School have both received honours at the London region Teaching Awards.
The awards were presented this week at a ceremony hosted by Riz Lateef of BBC London News.
Two of the 12 'Plato' awards for London teachers were given to staff at Southwark schools.
She was nominated for the award by a former pupil who credits the teacher with improving her GCSE grades after the class had been taught by a succession of supply teachers: "She rescued us. She is a complete saviour."
Carly, who previously worked as a complaints manager for the National Health Service, joined the school after impressing senior staff as a trainee during her teaching practice and is now a popular member of staff.
"Her affable manner and excellent sense of humour enable her to get on with a whole range of staff. She is in all respects a team-player," said one colleague.
A colleague said: "I never known a student who has not spoken highly of her."
As a form tutor, she has nurtured her current group from Year 7 to 11, and is extremely proud that the head girl, one of the two deputy head girls and 3 other members of the student leadership team come from her tutor group.
The judges said: "We have not come across a teacher of this breadth and calibre".
Richard Owens of St Saviour's and St Olave's received a distinction in the same category.
Dr Irene Bishop, headteacher of St Saviour's and St Olave's, received a commendation in the Royal Air Force Award for Headteacher of the Year in a Secondary School
For the latest local news and events direct to your inbox every Monday, you need our weekly email newsletter SE1 Direct.
7,000+ locals read it every week. Can you afford to miss out?
Read the latest issue before signing up