A branch of The Co-operative Food and a Carluccio's restaurant are to open at the Neo Bankside development.
Last year developers Native Land and Singapore's Hwa Hong Corporation spent more than £10 million acquring a 999 year lease on the retail space at Neo Bankside.
At the time Alasdair Nicholls, chief executive of Native Land, said: "We are offering retailers the opportunity to occupy a key site at the very epicentre of this dynamic and ever evolving neighbourhood."
Currently only the retail space at Pavilion B – Sir Terence Conran's Albion restaurant – is occupied.
For the latest local news and events direct to your inbox every Monday, you need our weekly email newsletter SE1 Direct.
7,000+ locals read it every week. Can you afford to miss out?
Read the latest issue before signing up